Cell Based Assays
Eurofins Discoverx PathHunter eXpress XBP1 Nuclear Translocation Assay, 2-Plate Kit. (93-0857E3CP5M)
The PathHunter eXpress XBP1 Nuclear Translocation Assay provides an easy-to-use cell based assay to study drug candidates affecting the IRE1/XBP1 pathway. This kit assesses ligand (e.g. thapsigargin) based pathway activation via detection of resulting XBP1 nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged XBP1 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of XBP1 leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Panitumumab Bioassay Kit, 10-Plate. (93-1051Y3-00094)
The PathHunter Panitumumab Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses EGF-induced dimerization of ErbB2 and EGFR receptors. This product uses EFC technology. The cell line included overexpresses ErbB2 target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of ErbB2 and EGFR, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Meso Scale Discovery RPLEX HUM Mcl1/BIM Complex ASY
The R-PLEX Human Mcl-1 Bim Complex Assay Kit from Meso Scale Discovery is used to quantitatively measure Mcl-1 and Bim protein interactions in cell or tissue lysates This electrochemiluminescent assay utilizes patterned arrays and MSD s proprietary SULFO-TAG labels for high sensitivity and low background The kit includes a 96-well plate coated with capture antibodies detection antibodies read buffer wash buffer blocker solutions SULFO-TAG labeled detection antibodies and calibrators to generate a standard curve This assay allows for the quantitative analysis of Mcl-1/Bim interactions involved in the regulation of apoptosis
Cytek Biosciences Inc Mu Treg Idenfitication Kit
Product Name: Cytek Tonbo Mouse Treg Idenfitication Kit
Cytek Catalog Number: 95-K301-T025
Product Class: Kits and Panels
Type: Panel
Size: 25 Tests
Eurofins Discoverx PathHunter eXpress CALCRL-RAMP2 (AM1) CHO-K1 β-Arrestin GPCR Assay, 2pl Kit. (93-0270E2CP0M)
The PathHunter CALCRL-RAMP2 (AM1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. adrenomedullin) based activation of CALCRL GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CALCRL and EA-tagged β-Arrestin-2, along with untagged modulating protein RAMP2. Activation of CALCRL stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress mEBI2 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0953E2MCP0L)
The PathHunter mEBI2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. dihydroxycholesterol) based activation of mEBI2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mEBI2 and EA-tagged β-Arrestin-2. Activation of mEBI2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress MCHR1 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0940E3CP5L)
The PathHunter MCHR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. MCH) based activation of MCHR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MCHR1 and EA-tagged β-Arrestin-2. Activation of MCHR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Mouse Insulin Receptor B (INSRb) Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Mouse Insulin Receptor B (INSRb) Stable Cell Line Functional Kinase Assay (U2OS) measures INSRb receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human DRD3 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human DRD3 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure DRD3 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human GHR-JAK2 Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Human GHR-JAK2 Stable Cell Line Functional Kinase Assay (U2OS) measures GHR cytokine receptor activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Meso Scale Discovery U-PLEX Mouse IL-15 ASY
The Meso Scale Discovery U-PLEX Mouse IL-15 Assay Kit is an electrochemiluminescent immunoassay for the quantitative measurement of mouse interleukin 15 (IL-15) in serum plasma and cell culture supernatants The assay uses MSD s proprietary SULFO-TAG labels and multi-array technology to provide sensitive and reproducible quantitation of mouse IL-15 with a lower limit of detection of 1 3 pg/mL and an upper limit of quantification of 10 000 pg/mL The kit includes a 96-well plate coated with capture antibody detection antibody conjugated to MSD SULFO-TAG calibrators and sample diluent The assay takes approximately 3 5 hours to complete after a 2 hour incubation
Meso Scale Discovery RPLEX HUM BclX/Bcl2L1 ASY
The R-PLEX Human Bcl-xL/Bcl2-L-1 Assay Kit from Meso Scale Discovery is used to quantitatively measure Bcl-xL and Bcl2-L-1 protein levels in human samples such as serum plasma and cell lysates The assay utilizes electrochemiluminescence (ECL) detection and provides high sensitivity broad dynamic range and rapid results This multiplex assay allows you to measure both proteins in a single well saving sample volume and time The kit includes a 96-well plate coated with capture antibodies detection antibodies calibrators and buffers needed to run the assay Results are obtained in as little as 3 5 hours
Eurofins Discoverx PathHunter eXpress CXCR1 (IL8RA) U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0226E3CP0L)
The PathHunter CXCR1 (IL8RA) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL8/IL8) based activation of CXCR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR1 and EA-tagged β-Arrestin-2. Activation of CXCR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Miltenyi Biotec, Inc. MACSfectin 0,5mL
Reagent for transfection of adherent and suspension cells maintaining high cell viability
Eurofins Discoverx cAMP Hunter eXpress PTGER2 DLD1 GPCR Assay, 2-Plate Kit. (95-0176E13CP25M)
The cAMP Hunter PTGER2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTGER2, a naturally Gs coupled GPCR. Upon activation of PTGER2, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.